Oklahoma lost receiver Dede Westbrook to a head injury in the first half, and running back Samaje Perine made a trip to the locker room in the fourth quarter after a knee to the back of his head resulted in a fumble in the red zone. 

But Joe Mixon picked up the slack, weaving through Oklahoma State's defense for a 79-yard touchdown that eliminated any fourth-quarter drama in the No. 9 Sooners' 38-20 Bedlam victory over No. 10 Oklahoma State with the Big 12 title at stake on a gray, rainy, cold Saturday at Owen Field. 

A play before Mixon's long run, the Cowboys' Ben Grogan missed a 38-yard kick that would have cut Oklahoma's lead to one possession. Instead, Mixon's touchdown stretched the Sooners' lead to three possessions and clinched Oklahoma's 10th Big 12 title and second consecutive league crown. 

The Sooners won't make a return trip to the playoff after struggling to a 1-2 start with losses to Houston and Ohio State, but they'll book a trip to the Sugar Bowl against an SEC opponent (most likely Auburn) and become the first Big 12 team to go undefeated in league play since the conference instituted a round-robin schedule in 2011. At 10-2, they'll head to New Orleans on a nine-game winning streak as one of the hottest teams in college football. 

Oklahoma State will likely head to the Alamo Bowl in San Antonio and face a Pac-12 opponent. 

After briefly leaving, Perine returned later in the fourth quarter, but Westbrook sat for the entire second half after catching four passes for 111 yards, highlighted by a 69-yard touchdown before an ugly hit with 6:58 to play in the first half ended his day. Oklahoma State's Jordan Sterns wasn't flagged for targeting on the hit.

The rain meant simplified duty for quarterback Baker Mayfield -- who announced after the game that he'll return in 2017 for his senior season -- but his elusiveness on broken plays terrorized the Cowboys in the first half. His first eight completions went for 237 passing yards, and the Sooners finished with 341 yards on the ground. 

Oklahoma State true freshman Justice Hill sprinted to a fast start, pushing the Cowboys to an early 17-10 lead. He finished with 99 yards on 16 carries to break the school's freshman rushing record and become the Cowboys' first 1,000-yard rusher since 2012. But it wasn't enough.

Just like last year's Bedlam, the Sooners' quarterbacks sported Fu Manchu facial hair. Even ex-Sooner and current Texas A&M Aggies QB Trevor Knight was on the sideline sporting the signature rivalry style. 

With a title at stake, the Fu Manchu bested The Mullet with a dominant running game and two key plays to swing the game's final period, putting Oklahoma in a familiar position atop the Big 12.